Tuberculosis: Clinical Policies and Program Manual

This manual describes policies, protocols and recommendations for the prevention, treatment and control of tuberculosis from the NYC Department of Health. It was written primarily for the medical providers of the New York City Bureau of Tuberculosis Control as a reference guide on tuberculosis diagnosis, treatment and prevention. The fifth edition was published in 2021.

While this manual is comprehensive and covers both routine and complex issues, it cannot and should not be substituted for the best judgment of individual providers in specific clinical situations. Those who use this manual are strongly encouraged to seek expert consultation when needed, particularly in special situations, such as drug-resistant tuberculosis. You can reach Health Department medical consultants at the TB Provider Hotline (844-713-0559) Monday to Friday, 8:30 a.m. to 5 p.m.

Select a specific chapter below:

• Chapter 1: Introduction (PDF)
• Chapter 2: Diagnosis and Treatment of Latent Tuberculosis Infection (PDF)
• Chapter 3: Diagnosis of Tuberculosis Disease in Adults (PDF)
• Chapter 4: Laboratory Testing for Tuberculosis (PDF)
• Chapter 5: Treatment of Drug-Susceptible Tuberculosis Disease in Adults (PDF)
• Chapter 6: Treatment of Drug-Resistant Tuberculosis Disease in Adults (PDF)
• Chapter 7: Diagnosis and Treatment of Pediatric Tuberculosis Disease (PDF)
• Chapter 8: Clinical Monitoring and Follow-Up for Tuberculosis Treatment (PDF)
• Chapter 9: Tuberculosis Reporting and Surveillance (PDF)
• Chapter 10: Case Management for Patients with Tuberculosis (PDF)
• Chapter 11: Contact Investigation (PDF)
• Chapter 12: Tuberculosis Genotyping and Cluster Investigation (PDF)
• Chapter 13: Infection Control (PDF)
• Chapter 14: Outreach and Education (PDF)
• Chapter 15: Tuberculosis Evaluation for New Arrivals and Status Adjusters (PDF)
• Chapter 16: Program Evaluation and Research (PDF)
• Chapter 17: Laws Governing Tuberculosis in New York City (PDF)
• Appendices (PDF)

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